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Pycnogenol Liquid Supplements Pycnogenol ® is a patented extract that many people take in the form of a liquid supplement. It is claimed to help with a number of conditions, such as attention deficit hyperactivity disorder (ADHD), high blood pressure, chronic venous insufficiency, and asthma. Pycnogenol is a patented pine tree bark extract from Pinus maritma trees located in southern France. Pycnogenol is a mixture of bioflavonoids and proanthocyanadins having enormous antioxidant properties. It is considered to be the strongest antioxidant available.